Zipaquir - Home hope Juan Sebastian Molano, riding for UAE Team Emirates, claimed his third stage win on the Tour Colombia on Saturday, just edging out Alvaro Hodeg and Jhonatan Restrepo.
With just Sunday's sixth and final stage to race up to El Verjon, Sergio Higuita of EF Pro Cycling still leads the overall standings.
He has a 12-second advantage over team-mates Daniel Martinez and with Jhonatan Caicedo a further two seconds off the pace.
"The last kilometre was complicated, it was a bit technical," Molano admitted to ESPN.
"Alvaro is very strong, he came out very hard, but I have very good legs and I'm taking advantage of the opportunities that the team gives me."
Tour de France winner Bernal, of Team Ineos and riding on home soil, is fourth overall with a 50-second deficit